Yes, sounds like meds need adjusted as well as perhaps thought patterns need monitored by you, such as: are you thinking of the past and future more then the "present" moment?

In "this" moment what are you thinking? Try very hard to see if your thoughts are relevant to what is currently happening? or is your mind wandering beyond the "now" in search of problems.

I find that depression that is not apparent in the morning or early afternoon is because we have not let our minds run amok yet, but as the day/night wheres on.. the "story of me" becomes so depressing do to negative thinking that it depresses us.

No doubt you have a chemical imbalance...I'm not minimizing that issue, but thinking beyond the now is destructive. I know, I've done it plenty of times when I've been totally and completely unconscious of what my own mind was doing to me.