Over the 22 years since I have been on meds, the longest I have stayed on a single combo of meds has been about 6mo to a year. After that, I need to have them tweaked, and some changed completely as they quit working for me. I know this all sounds disheartening, but remember, I have had some really good times which usually last 12-18 months at a time with periods of abnormal moods in between. What you have to ask yourself is, "What am I willing and able to do to keep myself as healthy as possible?" Then do it.