Thank you all so much for your replies. All of your posts where you describe your experiences with seroquel have really helped me. My number locks were on. I started out at 25mg which used to knock me out. Here we are about a year later and i'm up to 450mg. My doctor told me I could go up to XX amount of mg and to take it as needed. I'm really starting to think that this is not a casual "take as needed" drug but it works great for me some of the time. Does anyone else find that they go through a streak of nights where they get great sleep and then maybe the next week they have trouble sleeping? That's me. One interesting thing, I barely ever had a dream until I went on seroquel. It helped me achieve that deep sleep but it does take me forever to wake up in the morning. When I went from 450mg and then for 3 nights went down to 100mg, I became so depressed I almost went to the hospital. Thanks again everyone and hang in there!