I gained 20 pounds while on Seroquel. While it helped the anxiety/mania and let me really sleep for the first time in years, I began getting really depressed about the weight gain. I weaned myself off Seroquel. It just increased my appetite SO much. I think you have to "weigh" the pros and cons of being on Seroquel. For me, taking a Klonopin before bed helps me sleep and doesn't make me want to eat everything in the house! Hope this helps! Good luck!