I've never had problems due to drinking while on Wellbutrin that weren't the kind of problems that come with drinking in general. So no increase in side effects or anything, as far as I can tell. And I've definitely done my share of binge drinking while on Wellbutrin. And Effexor, Zoloft, and Prozac - I don't remember any problems with any of them that were related to alcohol. Of course, I did start hallucinating on a therapeutic dose of Prozac, but that was just the SSRI's reacting badly with my brains.

So as everyone says, YMMV and check with the pdocs first.