I have slowly made my way up to a dose of 550 mg of seroquel. I started at a dose of 25mg one year ago for sleep. It seems like especially over the last two weeks that I keep upping it and upping it still does not help me sleep. Well, my doctor a while back suggested to do what many of you are doing. He suggested to take some earlier in the day. However, yesturday I took 200mg at work and it made me feel so drugged it was embarassing. However, it sounds like for everyone else, by taking a really small dose during the day, it helps even out the effect for better sleep at night. I will try that. Your comments have really helped. THank you and sweet dreams.