Yes it could. Might take a while but eventually your liver is going to feel it. It has to process all that alcohol and oxy somehow. The poor thing is going to be tired eventually, hehe.

And please keep in mind (even though you probably already know) that taking alcohol on top of opiates like Oxy's can lead to the supression of your nervous system and death. I have seen many people die from this combination. It is definitely not pretty. Especially for the person who finds the body (like me).