I think isolation for me is about perceived opportunity; if I wanted to reach out, do I think there is someone I can reach out to who would care. That has two parts; whether I think there is someone I can reach out to -- that would take me having done the work to create some sort of relationship with someone and/or my believing if I reached out to X person they would respond -- and do I want to reach out.

Sometimes I reach out and think someone does/does not respond and sometimes I reach out and someone does not respond and sometimes I do not reach out and think someone won't respond if I do or I do not reach out, hope someone will reach in. Lot of iffy thinking in one, three, and four where it could all be dependent on me if I get a response or not.