Everyone reacts differently, but Cymbalta was my saviour. I switched from Lexapro because it KILLED my libido (and made my depression significantly worse, but hey...)

It helped both my depression and anxiety.

Initially, I gained weight but in retrospect, I think that was more about the depression and less about the drug. Recently (while still on the drug) I lost 20 pounds so I can't blame the med for making me gain weight when it's been relatively easy to take it all off.

I'm in the process of weaning off now (almost done) after over two years on but for me, it saved my life without most of the nasty side effects.

Hope this helps.

Feddy