A couple of antidepressants have made me manic, some have made me more depressed...some just didn't help. I can't really remember all of them. What I do know is that I'm on Zoloft right now, and I feel more balanced than I have in a long time. I am also taking Lamictal with it, however, and I personally think that it has been the Lamictal that is making the biggest difference. (Keeping in mind though, that Lamictal is not an anti-depressant!)