I'm confused since this post is in the first person, but in the profile I see "Here for a friend." It makes a difference.

Is there a therapist & psychiatrist current involved? Does this person live alone? Do people come & go in his life?

For what's told in the post, kaliope's description of what's worked certainly suggests a healthy-sounding approach for donsallthere. Can't help but wonder though whether some event didn't occur that relates to the fear of rejection linked to job resignation. Something seems missing.

I feel terrible for anyone who has suffered this long with nothing bringing even hope of improvement. Continuing to take the meds may actually be causing a worsening of the problems if it's not a currently-reviewed prescription.

I hope Don or someone close to him can arrange for a complete, professional evaluation if such has not been ongoing. If it has been, maybe a change of doctors/therapists is in order. My opinion only, of course, but no one should have the same treatment continued if it's not benefiting him.