That's my drug combo too. Still titrating up on Lamictal. Actually recently went down from 450mg to 300mg on the Wellbutrin (450mg is the max dose), and briefly had a little less anxiety but I can't say whether that's the meds or something else. When I went the other direction (300 to 450) I had migraines for a month! That had never happened before, and they kicked in right after I took my pills in the AM. But eventually it went away.