Hi, I totally know about isolation. I have only been leaving the house 1 time a week. My husband works and my daughter has a new boyfriend. My daughter getting a first major boyfriend has made me so sad. She is either on the phone with him, with him or in school. She is my last child. I wonder how I will get thru it.It makes me cry. My depression has gotten so bad,. I isolate. I blew off my doctors appt today, but am going in on monday.