please talk to your MD about your meds and how they are affecting your life.

it seems like you are doing the best you can under the circumstances. while your brother and father seem like they could do more - it's also doubtful that they will drastically change their behavior after many years of not doing much. however, if you need help from them, then you must ask for it. all you have to say is "i need help with (fill in blank)." that will transfer some of the responsibility to them. it sounds like you are doing a very good job with your niece. please give her priority over the rest of the family.

sometimes it seems the best one can do is hang in there. it feels depressing, i know. but, if it's the best you can do at the moment then you have to accept that. despite the difficulties, it sounds like you are holding your own. considering the circumstances, that is quite an achievement. i wish i could offer you more than "you're doing a great job!" compliment but it's all i can do. please continue to hand in there!