I had cognitive/memory problems when I was on 400 mg for the first time. This time that I'm on 400 mg, it's not that bad. I still have word finding issues, but not as bad as they were. I think it's because I spread the dose to 3 times a day, 200 mg in am, 100 mg at lunch, and 100 mg at dinner. Technically I'm supposed to take all 400 mg in the am, but when I was doing that, I was getting chest pains.