I've been on Abilify for about 5 years now and have had no major side effects. I take it in conjunction with Lamotrigine and the combination has stabilized my moods and moderated my depression (I also take Pamelor). Right now, in addition to my meds, I am working with a LCSW in cognitive behavior therapy and this has enabled me to begin to heal scars left from my childhood that have caused problems. With the combination of meds and therapy, I feel better than I have in years, knock on wood.