I took Effexor for years and loved it. It lifted me out of depression and helped me with my tendency toward social phobia. Two and a half years ago, due to life's circumstances, my depression deepened and I was put on Wellbutrin. That kicked off a raging mania (my first) that lasted for weeks. Diagnosed with Bipolar 1, complete with delusions, hallucinations, psychosis.......the whole nine yards. I've since been on Lamictal and Seroquel since and I'm still seriously depressed. Prozac did nothing to help; pdoc worries that anything else would kick me back into mania. I'm starting to like the sound of that.