I have been on seroquel for over a year. I take it primarily for sleep but it has helped with my mood as well as it is a calmer for manic stages of bipolar. I started on 25mg and now i'm up to 450mg. It's a funny drug. It's hard to find the right dose. You really have to play around with it to see how much you need and when. For the first long while I was on it, I woke up with a hangover feeling for a long time. Personally, I find the later I sleep in, the more likely I am to wake up feeling groggy. Overall, the drug has really helped me and i've had very few side effects. I hope you feel better soon!