I think you should focus on him as a person as much as "finding the right med combo". I am not saying this applies to you, but many times with children with issues it ends up with parents dragging them around doctors and seeing everything as a symptom that needs to be treated.

Not trying to simplify anything, but many teens go through quite wild days and it is not pathological. I guess the most you can do is provide safety net and understanding.

It's pretty hard to be a teen and looking for yourself... and when other factors interfere with it.... it can be almost unbearable.