I got fat! immediately! SEroquel definitely helped me get me sleeping while manic, however I was really groggy in the morning, slept through alarms, late to work, couldn't think until around 10am.
(my dose was 200mg)

Lots of people I know feel awesome with 25 or 50 without too much grog in the morning.
But at that time of my life i was on so much other crap its hard to tell.