Exactly.

I think you've hit upon why the simplistic explanation drug companies push (that depression is a result of chemicals in your brain not being in balance) is just that -- too simplistic to be true.

A state of balance suggests equilibrium, and it also suggests that we know what that equilibrium looks like in a "normal" brain and can measure it. The fact is, we can do neither.

Emotions and thoughts are really the result of a complex interaction between brain chemicals, experiences, personality, your social connections, and so much more. To pull out just one of those factors and focus all treatment on it seems to me, anyway, to be missing the subtle complexities of this disorder (and others).

Best,
DocJohn