I forget but I know it after a day or so. My moods start going everywhere and, for lack of another way of putting it, I turn into what borders on a lunatic. I strongly suspect most of the medications have a kick back effect that hits you if you start missing your meds. In other words--your symptoms will return but they will be much worst. I put an application on my IPhone that allows me to track my moods and set up med reminders. The reminders help a lot. I'm also thinking about asking my husband to remind me every night or at least check my pill minder when he gets a glass out of the cabinet. Anything that helps, right?