I started Emsam recently and have feel like there may actually be hope. I have bounced from med to med for decades. Nothing seemed to work for me. I think it may be too early to actually be feeling anything so soon and I'm also in an extensive cognitive outpatient program. I truly don't think I'm having a placebo effect because I am so skeptical of medication. I did get headaches the first few days, but haven't had one today. I hope I finally find the right med. Please... please... that would be such a relief.