I now am at the dose the pdoc wanted me at. 200 mg nite time and 25 mg one in the morning and one in the afternoon. It seems to have leveled out somewhat. Have very dry sinus but I handle that with nasel spray. I still a little fuzzy, but I dont feel like a rubber puppy that was only the first day. I dont know about the weightgain as I just started them. oh I dont feel any panic att. but still feel the presure in my chest a little unnerving but ok.