I've been on Seroquel timed release since last January--so, a year. I have not gained weight and it has been a very helpful med for me. I sleep well for the first time in years. Currently I'm on 100 mg about three hours before bedtime.

At first Seroquel didn't just numb me out, it put me into some kind of semi-walking coma. I mean, wow. I felt totally zonked. But that wears off in a few days. So don't freak out if it knocks you over at first. It WILL go away, and after that, it helps.

A lot of folks here have had problems with it though, so my experience isn't the only one. Still, for me, it's been a godsend. Good luck!