I went out on the web and looked Seroquel up. I noticed a number of people said they actually lost weight on the drug and attributed it to taking it in combination with Wellbutrin. I'm taking 100 mg extended release Wellbutrin (she switched me back to extended today, thank God) so I'm hoping that will curb any issues with increase in appetite. With exceptions of Prozac and Depo-Provera (otherwise known as the drug from hell) I've never had issues with weight gain, even when taking meds known for it, including birth control. Hopefully with diet and exercise it won't be an issue.