Well, I'm currently taking the XR version of Seroquel (350mg) but my experience is that it was quite easy to deal with the weight gain issue. My appetite did increase at first, but I fought it and ate a normal amount of food. The appetite side effect went away fast for me. I think if you eat a healthy amount of food and exercise on a regular basis, weight gain shouldn't be an issue. I'm not a professional though, by any means, so don't quote me on that!

My biggest side effect on Seroquel XR was the increased tiredness. At my highest dose (600mg), I was sleeping between 14-16 hours a day. Now on my current dosage, I sleep 9-11 hours a day, usually 9. This medication helps me with anxiety, mostly, but also helps me to get a good night's sleep. I also imagine that it helps prevent any psychotic symptoms that could occur.

Another annoying side effect I had in the beginning was Restless Leg Syndrome...fortunately it only lasted a couple of weeks. It was SO annoying though!

Overall, this med has been very helpful for me. I hope it's helpful for you too.