(((LylaJean))) - I'm very sorry your brother is sick and he's lucky to have you and your husband. I don't know a lot about schizophrenia but I do know some illegal drugs, even simple marijuana can make some susceptible to schizophrenia, especially ecstasy.

I can relate to the change you saw with your brother, although my own experience wasn't as bad as yours. My deceased brother was diagnosed many years ago with bipolar disorder. We were extremely close and he had such a wonderful vibrant personality. It was like someone took away my brother and replaced him with a different person. I made it clear I would always be there and loved him, but he wasn't able to reciprocate. I grieved the loss of his personality and I accepted him, but he just wasn't there. I hope your brother gets the right help and make sure he tells the doctors about the drug use.