I've been on different disaster of seroquel for years. I have experienced some wt gain but very minimal. However my antidepressant and migrant med have opposite effect of wt loss so they pretty much balance out. I will say taking it causes incredible munchies I just try and avoid them. I have severe sleep issues and it's the only med that helps . I prefer the immediate release over the XR. I take 200mg and with that I usually fall asleep in half an hour. As with many meds it's FDA approved for other conditions, it is an anipsychotic but I just call it my sleeping med!