I think it varies from person to person...but I think it took me longer than most people to get used to Seroquel's effects. Maybe it's because I'm a thinner person, so I can't handle as much? I don't know. But I do know that when we increased the meds, it always took a week or more to get used to the changes. I hope you find the right dosage as soon as possible - that zombie feeling isn't fun!