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FearsomeAnna said:

However, he tried several SSRIs before hitting on Wellbutrin and the side effects he had were horrendous -for instance, Zoloft caused him to shoot straight into this paranoid dysphoric state where he was angry and suspicious to the point of being scary, and Lexapro scared him to death when he kept feeling paralyzed during the night. Unsurprisingly, he's not really keen to go anywhere near anymore SSRIs.

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Hi, Anna!

This is one of those "one med may be wonderful for one person and awful for another."

I've been on Zoloft (100 mg) for 15 years and have no problems with it whatsoever. But that one's out since your boyfriend already tried it.

I also had hideous side effects from Wellbutrin. Regardless, my pdoc had me stay on it to pull me out of a severe depression. Now I'm weaning off it and those side effects are rearing their ugly head again (just not as severe as when I went on it, thank God.)

I was on Prozac when I began taking psych meds and everyone I've personally known on Prozac has done ok. Zoloft is basically a Prozac twin (I read an article recently where the other SSRI's developed soon after Prozac should really have been named Prozac 2, Prozac 3, etc.

I know this hasn't been much help, but my encouragement is for your boyfriend to work closely with his pdoc (assuming he gets one he feels comfortable with) and know there is a wide range of SSRI's now to try.

Wishing you both success with this.