Seroquel lithium lamictal and depakote are huge wt gain offenders so is remeron and risperdal. Topomax and lexapro are great because they take the wt off and are great mood stabilizers. I have had no problem with ability. I do take seroquel but just don't allow myself to eat when the munchies kick in that's where the majority of the wt comes from. I gained 50 lbs on depakote lithium and remeron they ended up not working and the wt came off.