I would recommend elavil, another Amitriptyline class medication often used for a variety of psychosomatic issues. Seroquel can take up to a couple weeks for a person to adjust to. If possible taking it at night to begin with will help in coping with the sedative effects but waking in the morning will be a bad time for the person taking it. I dislike many of the psychotropics because they can have dramatic effects on the way one perceives reality. Of course this may be why the prescribing doctor recommended it in the first place.

I would avoid Depakote unless the doctors believe his problems may be the result of over stimulation between the hemispheres of his brain. Anti-seizure medications may not have overly noticeable side effects but suppressing the brains natural communication with the rest of the body seems unhealthy for long term usage. Additionally while it is commonly prescribed many of these medications have no documentation as to how they actually work to improve certain conditions. Many current behavioral scientists and psychologists are beginning to find more correlation between the placebo effect and actual treatment then initially thought.

The way we perceive a medication to work will greatly impact its efficacy. Even proven medications become less effective if we believe they won't help us.

And having gone through a stage while a teen myself sometimes the best medication is proper communication. This is of course the most difficult and time consuming treatment for any condition but if it works it would greatly benefit the relationship between the two of you and the future relationships they will develop later in life.