I took the Seroquel Xr and gained 40 lbs over about 5 months ) my weight gain was from metabolic sysndrome ,I have been off seroquel Xr for ehhh 2 months now I have lost some but certainly not all .. maybe plain seroquel doesnt have as big of an weight effect as the xr .. Personally I loved the results ( mental health wise ) I got but the weight gain was outragious ..Im now on " weight neutral" meds and if I dont start really losing this weight I will probably throw the biggest fit ever .. My opinion im not going to gain so much weight as I would probably develop diabetes .. I have enough health problems I wont add more just to treat bipolar.

Good Luck let us know how your doing