SPD has wrecked many of our interpersonal relationships, made it difficult if not impossible for some of us to hold jobs, etc.. For those who don't know the symptoms:

http://psychcentral.com/disorders/sx30.htm
Neither desires nor enjoys close relationships, including being part of a family
Almost always chooses solitary activities
Has little, if any, interest in having sexual experiences with another person
Takes pleasure in few, if any, activities
Lacks close friends or confidants other than first-degree relatives
Appears indifferent to the praise or criticism of others
Shows emotional coldness, detachment, or flattened affectivity