I have a long history and have had symptoms of anxiety, depression, racing thoughts, irritability, agitation since 14 or so (I'm 48 now). I've been thru the mill with meds (you name it I've taken it) and ECT (full series) and can not get rid of sensitivity/irritability. It drains my mental/physical energy to the point where I can't think straight, can't hold a conversation, disorganized thoughts, etc. Haven't had one decent relationship in 30 years due to these problems. I've become a recluse and on SSDI last seven years. Dr. has tried all sorts of meds. It can be triggered and it can have no trigger - it just happens and I've never really gotten a break from it for 30 years except for a brief period when I was on paxil (then it sort of wore off or something after 3 years or so). I don't understand why some people don't irritate easily and others do. It has to be something biochemical and I don't get it and I'm never going to get a hold of it. Anyone have these issues?