Are we talking about sex or the possibility of a relationship?
In terms of relationships i can recall a few times...once a guy said no because he was seeing someone else and conveniantly forgot to tell me although not whilst he was leading me on

and there was another time when i fell head over heals for a girl who i imagine i probably still would have been with now but sadly she felt ashamed of herself and didn't want her family to find out she was attracted to women if things went further between us...oh and then there was the girl who was ok being with me so long as i was ok disappearing whenever her friends/family popper over. Not sure if she was just ashamed of me or her sexuality but either way that was another relationship which ended before i would have liked...