For me absolutely ! I feel out of touch and depersonalized from everyone! I'm on edge and moody and have frequent mood swings even on my anxiety meds. I don't know how else to really explain it. It's kind of out of body. You're there but your not. You want to be present u just can't. My anxiety keeps me so wound up I can't personalize with people and I just want to isolate and clam up. I just have to find myself a quiet place to calm down before I reenter any situation .