I have gained around 45 pounds now from these meds. The worst being the two Im on now. Seroquel and zoloft. Im coming off of seroquel but it looks like its going to be a long time before im off. I agree with hamster it seems they could make a new med that is weight neutral. All of your questions make perfect sense, but i have no answers either. Just another person struggling with the weight gain. Yuck.