I relate to this SO MUCH. For me, it started by working from home. I still do, but there are days I cannot follow through on my plans to go grocery shopping or do anything other than lock myself up in my room with a book or work.
I'm bipolar, and my anxiety levels got worse once I knew all the pain I was experiencing was from Fibromyalgia. That can increase a person's anxiety tenfold. The more life trauma I have experienced, the worse my anxiety has gotten.
How are you handling the situation with your knee? Is there a brace you can wear so you feel more stable?
I emphathize with you more than you could ever know, and wish you the absolute BEST.