midnight, you may be better taking it at night before bed. it can cause drowsiness from my understanding. I was on Lexapro (sister med of Celexa) and it caused me to be very zombie-like during the day. I guess I didn't feel any anxiety or depression because I didn't feel much of anything when I took it in the morning. if it makes you sleepy, try it at night. keep us posted on how it's working for you!