It took a long time! I was on 400 mgs at one point and that gave me a major case of the stupids and I was still depressed. We combined that with Celexa and my personality ceased to exist. My thoughts wouldn't come to me. That happens to some so, beware the stupids. On the plus side though, the ridiculously boring and menial tasks that your job requires will become even more tolerable. Just hope no one asks you a question