I don't know about the vegan/lifestyle thing, but I'm trying to reduce my meds, too. My pdoc yesterday suggested an OTC called SAMe. Says it has natural antidepressant effects and has proven to be far more effective than St John's Wort. It's shown well in clinical studies/human trials, etc. So it might be something to think about for a mood lift if you do need one off meds. It has none of the stuff in it that SJWort had.