I take 50 mg of seroquel and 1050 of lithium right now. (I just took it a few minutes ago, actually)

The only time ANYTHING like that happened, I had a lot of anxiety that day and as I was trying to sleep I couldn't really relax...so I don't attribute that to either the lithium or the seroquel.

I don't use seroquel for mania though. I use it as a sleep aide. I am afraid of taking any medications specifically prescribed to help a person sleep. With seroquel, if I REALLY want to, I can usually fight off the sedating effects, but they usually kick in within 40-1 hr of taking it.