yes, i cut the 25 mg in 1/4. i find that works just fine and if i wake up or feel i need more, i just take another 1/4. i have only needed 450 mg lithium for 35 yrs. (get tremors at anything higher) and only 1/2 of .5 mg klonopin daily to keep anxiety and agitation at bay. still concered about wt. gain, even on this low dose, but i sure slept well last night.