Can't pin for sure on the depression or the meds, but something sure drops the bottom out of my sex drive when I'm in a depressive episode. Opposite applies for mania too. During the 3-4 month mania I'm trying to recover from now, I spent more time in the sack, sometimes multiple times per day, than I had in the previous few years. Crash back into depression at the end of that one was horrible and I'm still not over it.