I get very irritable due to both depression and mania with my bipolar. The main thing for me is to recognize when I'm feeling irritable. I need to conciously be aware of it and be on guard with what I'm doing or saying and tone of voice, etc. This is especially hard working in customer service, but also of the most importance.
If it gets too bad I take a minute to go somewhere to sit quietly for a minute to try to collect myself.
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