First of all, I want it to be known that my luck has made it so that I always have major relapses or cycling during holidays, weekends, or my psychiatrists vacations. Just bad luck. Sucks.

Anywho, I have been on 150mg Zoloft for about 5 months but was off and on 100mg for about 3 years. I am also on .5 Klonopin once a day. The last 2 weeks I have been rapidly cycling from normal, to anxiety, to minor depression and back again. Yesterday I had a terrible anxiety day for about 90% of the day. Today I have had the worst depression/anxiety I have had in about 4 months. 4 months ago I was dealing with panic and major depression, but the zoloft and therapy brought me back to ide say 80-90% functionality. Now I am at about 25%. I have read a lot about "Prozac Poop Out" effect and how it can happen to any ssri. There is a similarity between how I feel today and how I felt before the zoloft. Of course it is Sunday, and im miserable but I cant talk to my psych until MAYBE Tommorow if he has a minute to call me which sometimes he doesn't. But anywho here is my question.

Anyone dealt with SSRI poop out and had success switching SSRIs? I am hearing and reading REALLY good things about Lexapro for people with anxiety and depression. I have tried prozac and that was a nightmare, and paxil ruined my friend's life for 2 years so im hesitant to even try that. So again, anyone have success after an SSRI poop out? How did you go about starting the new drug? How long until you felt better? Anyone think upping my Klonopin a bit during this transition will help make it smoother?

Thanks guys