I'm on 100mg of Zoloft after I tried Paxil and Paxil CR both of which made my depression worse and I was on Celexa and that had to be raised every month to finally I was at the maximum level my doctor could prescribe and it was a level that my insurance required a pre authorization for every 6 months because it was 60mg and that was the maximum dose...and the last part of me being on Celexa I was also on 50 mg of Trazodone and we increased the trazodone to 75mg and the Celexa still wasn't working so I stopped the Celexa and after a while of just being on the trazodone I told my doctor and she said that the trazodone couldn't be taken alone as an antidepressant so we tried 50mg of Zoloft.....that worked great and we increased it at the end of 2010 beginning of 2011. You may just need to have your Zoloft increased. If you can find it there's an over the counter herbal medication I take for increases in my stress and anxiety levels and it's called Calm's Forté. You can take 1-2 pills up to 3 times a day and then 1-3 pills at night to help you sleep. And it's safe to take with Zoloft. I still have cycles of PTSD related issues even though I'm on a bunch of meds for it. As my doctor puts it you'll have some good days and some bad days. If you've been feeling this way for a longer period of time than usual then I'd say you may need your Zoloft increased slightly. Unless you're at the maximum dose available of Zoloft then it hasn't pooped out and there might be room to increase it before having to switch to a new medication.