I have been taking Clozaril for about 17 years...I have been on doses as high as 800 mg a day. I went off my meds last march.Was put back on it this March...except I now only take 50 mg.That's all I need. My new Psychiatrist keeps insisting on increasing dose.... Yea because I was off for 6 months my labs are weekly....The only problem is that my diffrent alters have different CBC's and it confuses every body involved.